抗人膀胱癌抗独特型抗体诱导特异性迟发过敏反应的研究Induction of Specific Delayed Type Hypersensitivity with Anti-idiotypic Antibod y to Human Bladder Cancer
邵晋凯,范海涛,张明,刘禄成,郭航,刘险峰
摘要(Abstract):
目的研究对抗人膀胱癌抗独特型抗体(BC2)诱导的特异性迟发过敏反应(DTH)。方法经过BC2免疫的小鼠,用膀胱癌细胞系进行脚掌注射攻击后,测定脚掌水肿厚度判定DTH反应强度,并进行病理学检查。结果BC2诱导的DTH平均水肿厚度为0·95mm,与膀胱癌组织抗原组比较差异无显著意义(P>0·05);免疫鼠对胃癌细胞攻击呈阴性反应;BC2诱导的病变内可见大量炎性细胞,呈弥漫性浸润。结论BC2具有抗原模拟作用,可诱导特异性的DTH反应,可能成为膀胱癌防治的新途径。
关键词(KeyWords): 抗独特型抗体;膀胱癌;免疫
基金项目(Foundation): 卫生部科学研究基金资助(98-1-206)
作者(Author): 邵晋凯,范海涛,张明,刘禄成,郭航,刘险峰
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参考文献(References):
- [1]Schultes BC,Nicodemus CF.Using antibodies in tumor immunotherapy Expert Opin Biol Ther,2004,4:1265-1284.
- [2]McCarthy H,Ottensmeier CH,Hamblin TJ,et al.Anti-idiotype vaccine.Br J Haematol,2003,123:770-781.
- [3]范海涛,刘禄成,朱德淳,等.抗人膀胱癌抗独特型抗体的制备和鉴定.临床泌尿外科杂志,2002,17:553~555.
- [4]Nepom GT,Nelson KA,Holbeck SL.Induction of immunity to a human tumor marker by in vivo administration of anti-idiotypic antibodies in mice.Proc Natl Acad Sci USA,1984,81:2864-2866.
- [5]Jerne NK.The generative grammar of the immune system.Science,1985,229:1057-1059.
- [6]何小娟.肿瘤基因工程抗体抗体研究进展.国外医学肿瘤学分册,2002,29:245~248.
- [7]宋文冲.抗独特型抗体在抗肿瘤免疫中的研究现状.细胞与分子免疫学杂志,2002,18:678~680.
- [8]Stevenson FK,King A,Ottensmeier CH.Vaccine therapy in NHL:future promise and current limitations.Leuk Lymphoma,2003,44:85-90.
- [9]李官成,周国华,朱建高,等.具有鼻咽癌相关抗原内影像的抗独特型抗体研究.湖南医科大学学报,2000,25:319~322.
- [10]Liu Z,Panousis C,Smith FE,et al.Generation of anti-idiotype antibod-iesfor application in clinical immunotherapy laboratory analyses.Hybrid Hybridomics,2003,22:219-228.
- [11]郭占军,王旭光.Survivin在膀胱癌中的研究进展.国外医学泌尿系统分册,2004,24:338~341.