微生物来源抗肿瘤药物的研究进展Progress in research on anticancer drugs derived from microorganisms
魏艳红;尧晨光;奚彩丽;胡康洪;
摘要(Abstract):
自然界拥有丰富的微生物资源,可产生多种天然产物。许多产物含有抗肿瘤的活性成分,包括不同的结构类型:蛋白类、多糖类、蒽环类、有机酸酯类、萜类、生物碱类、大环内酯类及烯二炔类等,已有多种天然产物开发为药物应用于临床。本文就来源于陆地微生物、海洋微生物及共生微生物抗肿瘤药物的种类,微生物来源抗肿瘤药物面临的挑战和应对策略及其优势和发展前景等方面作一综述。
关键词(KeyWords): 微生物;天然产物;抗肿瘤药
基金项目(Foundation): 国家自然科学基金青年项目(31400153);; 湖北省自然科学基金重点项目(2014CFA075)
作者(Authors): 魏艳红;尧晨光;奚彩丽;胡康洪;
DOI: 10.13200/j.cnki.cjb.001697
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