杨晓明;侯继峰;

• 1:中国生物技术股份有限公司
• 2:中国食品药品检定研究院血液室

摘要(Abstract)：

随着康复期血浆(convalescent plasma,CP)被成功地用于治疗多种急性病毒性传染病,其独到的治疗技术优势越来越受到肯定和认同。新近在中国武汉发现并鉴定一种命名为2019-nCoV(SARS-CoV-2)的新型冠状病毒,目前暂无特异性治疗其感染的有效手段。本文就CP应用于埃博拉、大流行流感、严重急性呼吸综合征(severe acute respiratory syndrome,SARS)、中东呼吸综合征(Middle East respiratory syndrome,MERS)的现状作一综述,并对其治疗新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)的前景作一展望。

关键词(KeyWords)： 康复期血浆;大流行流感病毒;埃博拉病毒;SARS冠状病毒;MERS冠状病毒;新型冠状病毒;新型冠状病毒肺炎

Abstract:

Keywords:

基金项目(Foundation): 国家科技部重点专项“2019-nCoV感染恢复期患者特异性血浆和特异性球蛋白的制备”(2020YFC-0841800)

作者(Authors): 杨晓明;侯继峰;

DOI: 10.13200/j.cnki.cjb.003023

参考文献(References)：

• [1]EXNER SIMON L P A.Experimentalpoliomyelitisinmonkeys.SeventhNote:activeimmunization and passive serum protection[J].JAMA,1910,LIV:1780-1782.
• [2]LEIDER J P,BRUNKER P A,NESS P M.Convalescent transfusion for pandemic influenza:preparing blood banks for a new plasma product[J].Transfusion,2010,50(6):1384-1398.
• [3]CHENG Y,WONG R,SOO Y O,et al.Use of convalescent plasma therapy in SARS patients in Hong Kong[J].Eur J Clin Microbiol Infect Dis,2005,24(1):44-46.
• [4]ARABI Y,BALKHY H,HAJEER A H,et al.Feasibility,safety,clinical,and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection:a study protocol[J].Springerplus,2015,4(1):709.
• [5]HUNG F,TO K K,LEE C K,et al.Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A(H1N1)2009 virus infection[J].Clin Infect Dis,2011,52(4):447-456.
• [6]FRAME J D,VERBRUGGE G P,GILL R G,et al.The use of Lassa fever convalescent plasma in Nigeria[J].Trans R Soc Trop Med Hyg,1984,78(3):319-324.
• [7]MAIR-JENKINS J,SAAVEDRA-CAMPOS M,BAILLIE J K,et al.The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology:a systematic review and exploratory meta-analysis[J].J Infect Dis,2015,211(1):80-90.
• [8]Report of an International Commission.Ebola haemorrhagic fever in Zaire,1976[J].Bull World Health Organ,1978,56(2):271-293.
• [9]EMOND R T,EVANS B,BOWEN E T,et al.A case of Ebola virus infection[J].Br Med J,1977,2(6086):541-544.
• [10]MUPAPA K,MASSAMBA M,KIBADI K,et al.Treatment of Ebola hemorrhagic fever with blood transfusions from convalescent patients.International Scientific and Technical Committee[J].J Infect Dis,1999,179(Suppl 1):S18-S23.
• [11]VAN GRIENSVEN J,De WEIGGGELEIRE A,DELAMOU A,et al.The use of Ebola convalescent plasma to treat Ebola virus disease in resource-constrained settings:a perspective from the field[J].Clin Infect Dis,2016,62(1):69-74.
• [12]MORA-RILLO M,ARSUAGA M,RAMIREZ-OLIVENCIA G,et al.Acute respiratory distress syndrome after convalescent plasma use:treatment of a patient with Ebola virus disease contracted in Madrid,Spain[J].Lancet Respir Med,2015,3(7):554-562.
• [13]VAN GRIENSVEN J,EDWARDS T,DE LAMBALLERIE X,et al.Evaluation of convalescent plasma for Ebola virus disease in guinea[J].N Engl J Med,2016,374(1):33-42.
• [14]HUNG I F,TO K K,LEE C K,et al.Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A(H1N1)2009 virus infection[J].Clin Infect Dis,2011,52(4):447-456.
• [15]HANSON B J,BOON A C,LIM A P,et al.Passive immunoprophylaxis and therapy with humanized monoclonal antibody specific for influenza A H5 hemagglutinin in mice[J].Respir Res,2006,7:126.
• [16]ZHOU B,ZHONG N,GUAN Y.Treatment with convalescent plasma for influenza A(H5N1)infection[J].N Engl J Med,2007,357(14):1450-1451.
• [17]KSIAZEK T G,ERDMAN D,GOLDSMITH C S,et al.Anovel coronavirus associated with severe acute respiratory syndrome[J].N Engl J Med,2003,348(20):1953-1966.
• [18]DROSTEN C,GUNTHER S,PREISER W,et al.Identification of a novel coronavirus in patients with severe acute respiratory syndrome[J].N Engl J Med,2003,348(20):1967-1976.
• [19]PEIRIS J S,LAI S T,POON L L,et al.Coronavirus as a possible cause of severe acute respiratory syndrome[J].Lancet,2003,361(9366):1319-1325.
• [20]RABENAU H F,BIESERT L,SCHMIDT T,et al.SARS-coronavirus(SARS-CoV)and the safety of a solvent/detergent(S/D)treated immunoglobulin preparation[J].Biologicals,2005,33(2):95-99.
• [21]ZAKI AM,VAN BOHEEMEN S,BESTEBROER TM,et al.Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia[J].N Engl J Med,2012,367(19):1814-1820.
• [22]World Health Organization.Middle East respiratory syndrome coronavirus(MERS-CoV)[EB/OL].(2019-11-30)[2020-02-18].http：//www.who.int/emergencies/mers-cov/en/.
• [23]MAIR-JENKINS J,SAAVEDRA-CAMPOS M,Baillie J K,et al.The effectiveness of convalescent plasma and hyperimmune imm-unoglobulin for the treatment of severe acute respiratory infections of viral etiology:a systematic review and exploratory meta-analysis[J].J Infect Dis,2015,211(1):80-90.
• [24]KO J H,SEOK H,CHO S Y,et al.Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection:a single centre experience[J].Antivir Ther,2018,23(7):617-622.
• [25]World Health Organization.Novel coronavirus(2019-n CoV)situation report-15[EB/OL].(2020-02-04)[2020-02-05].https：//www.who.int/docs/default-source/coronaviruse/situationreports/20200204-sitrep-15-ncov.pdf?sfvrsn=88fe8ad6_2.
• [26]WANG D,HU B,HU C,et al.Clinical characteristics of 138hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan,China[J].JAMA,Published online February07,2020.
• [27]LOZANO M,CID J,MULLER T H.Plasma treated with methylene blue and light:clinical efficacy and safety profile[J].Transfus Med Rev,2013,27(4):235-240.
• [28]MARKUS EICKMANN,UTE GRAVEMANN,WIEBKE HAD-KE,et al.Inactivation of Ebola virus and Middle East respirato-ry syndrome coronavirus in platelet concentrates and plasma by ultraviolet light and methylene blue plus visible light,respectively[J].Transfusion,2018,58(9):2202-2207.
• [29]NOENS L,VILARINO M D,MEGALOU A,et al.International,prospective haemovigilance study on methylene blue-treated plasma[J].Vox Sang,2017,112(4):352-359.
• [30]KRAFT C S,HEWLETT A L,KOEPSELL S,et al.The Use of TKM-100802 and Convalescent Plasma in 2 Patients With Ebola Virus Disease in the United States[J].Clin Infect Dis,2015,61(4):496-502.
• [31]CAO WC,LIU W,ZHANG PH,et al.Disappearance of antibodies to SARS-associated coronavirus after recovery[J].N Engl J Med,2007,357(9797):1162-1163.
• [32]XIE L,LIU Y,FAN B,et al.Dynamic changes of serum SARS-coronavirus IgG,pulmonary function and radiography in patients recovering from SARS after hospital discharge[J].Respir Res,2005,6(1):5.