干扰素γ生物学功能及其应用的研究进展Progress in Research on Biological Function and Application of Interferon γ
田园;丁壮;岳玉环;
摘要(Abstract):
干扰素γ(Interferon gamma,IFNγ)是体内重要的细胞因子,能够通过调控免疫相关基因的转录协调机体的免疫反应。本文对IFNγ的生物学功能(主要包括诱导机体的抗病毒状态、抑制细胞增殖、诱导细胞凋亡、免疫调节)及其应用的研究进展作一综述。
关键词(KeyWords): 干扰素γ;生物学功能;治疗应用
基金项目(Foundation):
作者(Authors): 田园;丁壮;岳玉环;
DOI: 10.13200/j.cjb.2010.10.118.tiany.016
参考文献(References):
- [1]Schroder K,Hertzog PJ,Ravasi T,et al.Interf eron-gamma:an overview of signals,mechanisms and functions[J].J Leukoc Biol,2004,75(2):163-189.
- [2]Groettrup M,Khan S,Schwarz K,et al.Interferon-gamma inducible exchanges of20S proteasome active site subunits:why[J].Biochimie,2001,83(3-4):367-372.
- [3]Decker T,Stockinger S,Karaghiosoff M,et al.IFNs and STATs in innate immunity to microorganisms[J].J Clin Invest,2002,109(10):1271-1277.
- [4]Waldburger JM,Masternak K,Muhlethaler-Mottet A,et al.Lessons from the bare lymphocyte syndrome:molecular mechanisms regu-lating MHC class II expression[J].Immunol Rev,2000,178:148-165.
- [5]Ferris RL,Whiteside TL,Ferrone S.Immune escape associated with functional defects in antigen-processing machinery in head and neck cancer[J].Clin Cancer Res,2006,12(13):3890-3895.
- [6]Del Vecchio M,Bajetta E,Canova S,et al.Interleukin-12:biologi-cal properties and clinical application[J].Clin Cancer Res,2007,13(16):4677-4685.
- [7]Malathi K,Paranjape JM,Bulanova E,et al.A transcriptional sig-naling pathway in the IFN system mediated by2'-5'-oligoadenylate activation of RNase L[J].Proc Natl Acad Sci USA,2005,102(41):14533-14538.
- [8]Das S,Ward SV,Tacke RS,et al.Activation of the RNA-dependent protein Kinase PKR promoter in the absence of interferon is depen-dent upon Sp proteins[J].J Biol Chem,2006,281(6):3244-3253.
- [9]García MA,Gil J,Ventoso I,et al.Impact of protein kinase PKR in cell biology:from antiviral to antiproliferative action[J].Microbiol Mol Biol Rev,2006,70(4):1032-1060.
- [10]Zhou A,Paranjape JM,Der SD,et al.Interferon action in triply deficient mice reveals the existence of alternative antiviral path-ways[J].Virology,1999,258(2):435-440.
- [11]Takami K,akuwa N,Okazaki H,et al.Interferon-gamma inhibits hepatocyte growth factor-stimulated cell proliferation of human bronchial epithelial cells:upregulation of p27(kip1)cyclin-de-pendent kinase Inhibitor[J].Am J Respir Cell Mol Biol,2002,26(2):231-238.
- [12]Giroux M,Schmidt M,Descoteaux A.IFN-gamma-induced MHC class II expression:transactivation of class II transactivator pro-moter IV by IFN regulatory factor-1is regulated by protein kinase C-α[J].J Immunol,2003,171(8):4187-4194.
- [13]Bernabei P,Coccia EM,Rigamonti L,et al.Interferon-gamma re-ceptor2expression as the deciding factor in human T,B,andmyeloid cell proliferation or death[J].J Leukoc Biol,2001,70(6):950–960.
- [14]Nishiguchi S,Tamori A,Kubo S,et al.Effect of long term postop-erative interferon therapy on intrahepatic recurrence and survival rate after resection of hepatitis C virus-related hepatocellular carci-noma[J].Intervirology,2005,48(1):71-75.
- [15]Lin SM,Lin CJ,Hsu CW,et al.Prospective randomized controlled study of interferon-alpha in preventing hepatocellular carcinoma recurrence after medical ablation therapy for primary tumors[J].Cancer,2004,100(2):376-382.
- [16]丁丁,胡超,刘安东,等.重组人干扰素-γ对腭裂术后裸露骨面瘢痕成纤维细胞的影响[J].安徽医科大学学报,2009,44(1):72-75.
- [17]周荣,刘良明,胡德耀,等.γ-干扰素对过氧化氢诱导血管内皮氧化应激损伤的作用研究[J].中国危重病急救医学,2009,21(9):540-543.
- [18]张京滨.大剂量γ-干扰素治疗儿童病毒性脑炎[J].医师进修杂志,2003,26(5):33.
- [19]纪晓光,赵艳红,张敏,等.α-干扰素和γ-干扰素以及联合作用体外抗SARS-CoV试验研究[J].解放军药学学报,2008,24(3):268-269.
- [20]Jeong WI,Park O,Gao B.Abrogation of the antifibrotic effects of nactural killer cells/interferon-gamma contributes to alcohol ac-celeration liver fibrosis[J].Gastroenterology,2008,134(1):248-258.
- [21]Weng HL,Wang BE,Jia JD,et al.Effect of interferon-gamma on hepatic fibrosis in chronic hepatitis B virus infection:a random-ized controlled study[J].Clin Gastroenterol Hepatol,2005,3(18):819-828.
- [22]Ziesche R,Hofbauer E,Wittmann K,et al.A preliminary study of long-term treatment with interferon gamma-1b and low-dose pred-nisolone in patients with idiopathic pulmonaryfibrosis[J].N Engl J Med,1999,341(17):1264-1269.
- [23]Pockros PJ,Jeffers L,Afdhal N,et al.Final results of a double-blind,placebo-controlled trial of the antifibrotic efficacy of inter-feron-gamma1b in chronic hepatitis C patients with advanced fi-brosis or cirrhosis[J].Hepatology,2007,45(3):569-578.
- [24]Raghu G,Brown KK,Bradford WZ,et al.A placebo-controlled tri-al of interferon gamma-1b in patients with idiopathic pulmonary fi-brosis[J].N Engl J Med,2004,350(2):125-133.
- [25]蓝艳,唐秀生,武洁,等.SLE与γ干扰素的基因型及血清水平的相关性[J].中国皮肤性病学杂志,2009,23(2):81-83.
- [26]Ben-Ari Z,Mor E,Papo O,et al.Cytokine gene polymorphisms in patients infected with hepatitis B virus[J].Am J Gastroenterol,2003,98(1):144-150.
- [27]汪先桃,曾照芳.γ-干扰素、腺苷脱氨酶和新喋呤对结核性胸膜炎的诊断价值[J].重庆医科大学学报,2008,33(8):987-989.
- [28]孟晓丽,弓鸿飞,殷国荣,等.重组人干扰素γ联合弓形虫STAg鼻内免疫小鼠的免疫保护作用[J].中国生物制品学杂志,2009,22(5):483-485.
- [29]弓鸿飞,刘红丽,孟晓丽,等.弓形虫可溶性速殖子抗原联合IFNγ滴鼻免疫小鼠诱导的免疫应答[J].中国生物制品学杂志,2009,22(7):682-685.
- [30]王云龙,李玲玲,李晨阳,等.猪γ-干扰素基因的合成、表达及纯化[J].中国生物制品学杂志,2007,20(7):511-514.
- [31]田园,祝令伟,张国利,等.猪干扰素γ的原核表达及抗血清的制备[J].中国生物制品学杂志,2010,23(4):416-418,424.