重组人干扰素的研究进展Progress in Research on Recombinant Human Interferon
赵广荣;
摘要(Abstract)：
重组人干扰素(Recombinant human interferon,rhuIFN)是一类抗病毒、抗肿瘤和多发性硬化调节免疫的重要生物制品。自1957年发现干扰素以来,人们不断采用新技术对干扰素分子结构进行改造,先后研发了原型干扰素、保守干扰素、聚乙二醇修饰干扰素等几十个品种,目前已批准十余个一类新药干扰素上市。本文在回顾干扰素药物历史的基础上,对化学修饰改型干扰素、融合干扰素、杂合干扰素等的研究进展作一综述。
关键词(KeyWords)： 重组人干扰素;干扰素α;化学修饰改型干扰素;融合干扰素;杂合干扰素
基金项目(Foundation): 国家基础研究计划项目(2007CB714301);; 天津市自然科学基金项目(06YFJMC07300)
作者(Authors): 赵广荣;
DOI: 10.13200/j.cjb.2010.12.111.zhaogr.001
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