耿兴良;廖国阳;

• 1:中国医学科学院北京协和医学院医学生物学研究所

摘要(Abstract)：

目前,疫苗接种仍是预防流感最有效的途径,流感疫苗主要有三价灭活疫苗和减毒活疫苗。灭活疫苗虽安全有效,但其抗原用量大,生产过程复杂,生产周期长,且黏膜免疫力弱;而流感病毒减毒活疫苗不仅能诱导机体产生抗体,同时可引起包括黏膜免疫和细胞免疫在内的一系列适应性免疫反应,因此,认为其免疫效果优于灭活疫苗。本文就流感减毒活疫苗的研究历史及现状、疫苗候选株的获得及基于细胞的流感减毒活疫苗的研发作一综述。

关键词(KeyWords)： 流感病毒减毒活疫苗;反向遗传技术;候选株

Abstract:

Keywords:

基金项目(Foundation): 国家高技术研究发展计划(863计划)项目(2012AA02A4-04);; 国家科技部国际科技合作项目(2011DFR30420)

作者(Author): 耿兴良;廖国阳;

Email:

DOI: 10.13200/j.cnki.cjb.001623

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